Yeast as an Extrinsic Factor in Relation to Pernicious Anemia.
نویسندگان
چکیده
Wintrobe (1) recently stated that certain patients with typical pernicious anemia could be thrown into complete remission by oral treatment with dried, unautolyzed yeast, and he concluded that there was in the yeast some hematopoietic factor specific for the disease. As further argument for this belief, he stated that the addition of normal human gastric juice did not increase the potency of yeast more than it increased the potency of liver extract. Other workers have previously reported successful treatment of pernicious anemia with preparations of autolyzed (2) and unautolyzed (3) yeast. In this report we give our observations on 2 patients with typical Addisonian pernicious anemia in relapse, who were treated with yeast in the manner outlined by Wintrobe. The response obtained was then compared with the response from material of known hematopoietic activity. Both patients showed absence of free hydrochloric acid after subcutaneous administration of 1.0 mgm. of histamine. Patient C. W. was given ordinary brewer's yeast daily for 10 days (Figure 1). The attempt was made to administer 2 grams of yeast per kgm. of body weight, but the patient was not always able to take this amount. She never took less than 1.0 gram per kgm. of body weight, however, and consumed a daily average of 1.7 grams per kgm. of body weight over the 10-day period. During the test periods the diet contained no liver, meat, or eggs. On the sixth day, the reticulocyte count rose to 2.0 per cent. After 10 days, regular commercial ventriculin (Parke, Davis and Co.)
منابع مشابه
Xxxiv. Note on the Non-identity of Lactoflavin and the "extrinsic Factor" in Pernicious Anaemia. by Charles Amos Ashford, Louis Klein And
متن کامل
Effects of Gastro-Intestinal Resections in Swine on the Anti-Anemia Potency of the Liver
Shortly after Minot and Murphy37 announced the successful treatment of Addison's pernicious anemia with liver, Castle and his associates3 6,8,9 clearly established a fundamental relationship between a defect in gastric secretion and the occurrence of pernicious anemia. Evidence was presented that gastric juice from normal individuals contained in abundance an unidentified thermolabile substance...
متن کاملNotes on Some Remedies. XVIII. Drugs in Anæmias. Part II
Yeast which is rich in B group of vitamins has been used in ansemia with variable results. On the other hand marmite, an autolysed yeast product, has been effective in certain macrocytic anaemias especially tropical nutritional anaemia and pregnancy anaemia. The nature of the active factor has not yet been determined. The response of pernicious anaemia to marmite is however poor, though it is o...
متن کاملThe Effect of Avitaminosis on Hematopoietic Function
During the past few years medical science has made rapid advances in the therapeutics of pernicious anemia by dietotherapy. Stimulated by the researches of Whipple and Robscheit-Robbins (1) on the influence of the diet on blood regeneration in severe anemia in the dog, Minot and Murphy (2) have achieved marked success with liver diets in most accentuated cases of pernicious anemia. Cohn and cow...
متن کاملEffects of Vitamin B12 in Neonates and Young Infants
Vitamin B12 (cobalamin) is an essential coenzyme for nucleic acid synthesis. Animal protein is the major dietary source of vitamin B12. Deficiency of vitamin B12 leads to megaloblastic anemia, degeneration of the brain, spinal cord, peripheral nerves, and abnormalities of epithelial tissues. Two factors are necessary for the cure of megaloblastic anemia: one in food (extrinsic factor) and one i...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- The Journal of clinical investigation
دوره 18 3 شماره
صفحات -
تاریخ انتشار 1939